Upgrade 5.0.51a to 5.1.51 (no replies)

Hi
I intend to upgrade mysql from 5.0.51a to 5.1.51,so I want compile mysql from source.
our database use InnoDB as engine and has 200M record (15G)
May This upgrade cause any problem?
Of course I intend to use InnoDB Plugin as engine not Mysql built-in InnoDB.

Thanks for sharing any experience.